Host response mediators in coronavirus infection – ARBs CORONA II

A pan-Canadian randomzied controlled trial of an ARB (losartan) vs. usual care and mortality of COVID-19. Evaluation of ACE pathway proteins, proteomics and metabolomics as biomarkes of response to losartan and outome of COVID-19. 

More details on the clinical trial can be found here.

Related publications from ARBS CORONA I:

  1. Best JR et al. Early increases in anti-SARS-CoV-2 antibody isotypes associated with organ dysfunction and mortality in patients hospitalized with COVID-19. 

    Intensive Care Med. 2022 May;48(5):616-618. doi: 10.1007/s00134-022-06662-9. 

  2. Mohammed Y et al. Longitudinal Plasma Proteomics Analysis Reveals Novel Candidate Biomarkers in Acute COVID-19. J Proteome Res. 2022 Apr 1;21(4):975-992. doi: 10.1021/acs.jproteome.1c00863.

  3. Cheng MP et al. Acute Cardiac Injury in Coronavirus Disease 2019 and Other Viral Infections-A Systematic Review and Meta-Analysis. Crit Care Med. 2021 Sep 1;49(9):1558-1566. doi: 10.1097/CCM.0000000000005026.

  4. Lee T et al. Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors in COVID-19: Meta-analysis/Meta-regression Adjusted for Confounding Factors. CJC Open. 2021 Jul;3(7):965-975. doi: 10.1016/j.cjco.2021.03.001. Epub 2021 Apr 6.

  5. Lee T et al. Organ dysfunction and death in patients admitted to hospital with COVID-19 in pandemic waves 1 to 3 in British Columbia, Ontario and Quebec, Canada: a cohort study. CMAJ Open. 2022 Apr 19;10(2):E379-E389. doi: 10.9778/cmajo.20210216

Project Details

Funder/sponsor(s): CIHR
Lead institution: St Paul's Hospital
Status: Completed
Theme(s): Management

Project Lead(s): Jim Russell
Collaborators: John Boyd, Keith Walley, Srinivas Murthy, David Sweet Steven Reynolds, Gregory Reynolds
Trainee(s): N/A

First Nations land acknowledegement

Action on Sepsis operates on the traditional, ancestral, and unceded territory of the Coast Salish peoples — xʷməθkʷəy̓əm (Musqueam), Sḵwx̱wú7mesh (Squamish), and Səl̓ílwətaʔ/Selilwitulh (Tsleil-Waututh) Nations. We invite everyone to reflect on the traditional territories and land that they currently work and live on.

Action on Sepsis Research Cluster

Research Excellence Clusters at UBC Vancouver is a joint initiative of the Provost and Vice-President, Academic, UBC Vancouver and the Vice-President, Research and Innovation. Funding support for the clusters is provided by Academic Excellence Funds – UBC Vancouver.

UBC Crest The official logo of the University of British Columbia. Urgent Message An exclamation mark in a speech bubble. Caret An arrowhead indicating direction. Arrow An arrow indicating direction. Arrow in Circle An arrow indicating direction. Arrow in Circle An arrow indicating direction. Chats Two speech clouds. Facebook The logo for the Facebook social media service. Information The letter 'i' in a circle. Instagram The logo for the Instagram social media service. External Link An arrow entering a square. Linkedin The logo for the LinkedIn social media service. Location Pin A map location pin. Mail An envelope. Menu Three horizontal lines indicating a menu. Minus A minus sign. Telephone An antique telephone. Plus A plus symbol indicating more or the ability to add. Search A magnifying glass. Twitter The logo for the Twitter social media service. Youtube The logo for the YouTube video sharing service.