Identifying and evaluating the role of endotypes in sepsis diagnosis and treatment

Sepsis is a very complex disease, consisting of phenotypic clusters of patients, that constitute distinct endotypes, which are biologically-driven and relevant to clinical outcomes. We investigating whether genomics (RNA-seq and machine learning) can be used to diagnosis sepsis at time of admission, based on the 4 separate endotypes (subtypes) found in sepsis patients. We are currently conducting a multi-site study in colllaboration with institutions in Canada, Australia, Columbia, the Netherlands, USA, and Uganda.


First Nations land acknowledegement

Action on Sepsis operates on the traditional, ancestral, and unceded territory of the Coast Salish peoples — xʷməθkʷəy̓əm (Musqueam), Sḵwx̱wú7mesh (Squamish), and Səl̓ílwətaʔ/Selilwitulh (Tsleil-Waututh) Nations. We invite everyone to reflect on the traditional territories and land that they currently work and live on.


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