MOSAIC: Mix and match of the second COVID-19 vaccine dose for Safety and ImmunogeniCity

MOSAIC-1:

The initial MOSAIC study is comparing the effectiveness, safety, and acceptability of different dosing schedules of the first two doses of COVID-19 vaccines. That study began in June 2021 and is ongoing at 7 clinical sites in Canada where 195 participants were enrolled and received either both of their vaccines or the second authorized COVID-19 vaccine. Assessment is ongoing.

MOSAIC-2:

In this study we will evaluate the safety, tolerability, and immune response (resulting protection) of a third dose of a COVID-19 vaccine currently authorized in Canada (either the Pfizer-BioNTech or Moderna mRNA vaccine) in people who had two doses of COVID-19 vaccines at least six months ago.

Project Details

Funder/sponsor(s): Public Health Agency of Canada (COVID-19 Immunity Task Force)
Lead institution: Clinical Trials Network of the Canadian Immunization Network (CIRN)
Status: Active/Ongoing
Theme(s): Prevention, Population and Public Health

Project Lead(s): Manish Sadarangani Joanne Langley
Collaborators: Shelly Bolotin, Todd Hatchette, Scott Halperin, Tania Watts, Galit Alter, Joanne Langley
Trainee(s): N/A

First Nations land acknowledegement

Action on Sepsis operates on the traditional, ancestral, and unceded territory of the Coast Salish peoples — xʷməθkʷəy̓əm (Musqueam), Sḵwx̱wú7mesh (Squamish), and Səl̓ílwətaʔ/Selilwitulh (Tsleil-Waututh) Nations. We invite everyone to reflect on the traditional territories and land that they currently work and live on.

Action on Sepsis Research Cluster

Research Excellence Clusters at UBC Vancouver is a joint initiative of the Provost and Vice-President, Academic, UBC Vancouver and the Vice-President, Research and Innovation. Funding support for the clusters is provided by Academic Excellence Funds – UBC Vancouver.

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