Sepsis is a very complex disease, consisting of phenotypic clusters of patients, that constitute distinct endotypes, which are biologically-driven and relevant to clinical outcomes. We investigating whether genomics (RNA-seq and machine learning) can be used to diagnosis sepsis at time of admission, based on the 4 separate endotypes (subtypes) found in sepsis patients. We are currently conducting a multi-site study in colllaboration with institutions in Canada, Australia, Columbia, the Netherlands, USA, and Uganda.
Project Details
Lead institution: University of British Columbia
Status: Active/Ongoing
Theme(s): Diagnosis, Management
Project Lead(s): Bob Hancock
Collaborators: David Sweet
Trainee(s): N/A
First Nations land acknowledegement
Action on Sepsis operates on the traditional, ancestral, and unceded territory of the Coast Salish peoples — xʷməθkʷəy̓əm (Musqueam), Sḵwx̱wú7mesh (Squamish), and Səl̓ílwətaʔ/Selilwitulh (Tsleil-Waututh) Nations. We invite everyone to reflect on the traditional territories and land that they currently work and live on.