We have defined 5 sepsis endotypes in a large clinical study and propose to extend this here to severely ill COVID-19 patients. We will collect blood from up to 200 patients in BC and Quebec, and analyze the genes that are expressed in these cells (which will enable us to discriminate endotypes). This will allow us to define a set of genes for which the levels of expression correlate with future disease severity. This information will allow the development of a diagnostic that will enable a physician to predict the likely severity of a patient's disease and apply knowledge-driven clinical management. Furthermore, since endotypes operate under distinct mechanisms this knowledge will enable the discovery, by others, of targeted therapies to treat COVID-19 associated sepsis.
Project Details
Funder/sponsor(s): CIHR
Lead institution: University of British Columbia
Status: Active/Ongoing
Theme(s): Diagnosis
Project Lead(s): Bob Hancock
Collaborators: John Boyd Amy Lee, Roger Levesque
Trainee(s): N/A
First Nations land acknowledegement
Action on Sepsis operates on the traditional, ancestral, and unceded territory of the Coast Salish peoples — xʷməθkʷəy̓əm (Musqueam), Sḵwx̱wú7mesh (Squamish), and Səl̓ílwətaʔ/Selilwitulh (Tsleil-Waututh) Nations. We invite everyone to reflect on the traditional territories and land that they currently work and live on.