MOSAIC: Immunogenicity and adverse events following immunization with alternate schedules of COVID-19 vaccines in Canada

Learn more on the project website.

MOSAIC-1 (completed):

The initial MOSAIC study is comparing the effectiveness, safety, and acceptability of different dosing schedules of the first two doses of COVID-19 vaccines. That study began in June 2021 and is ongoing at 7 clinical sites in Canada where 195 participants were enrolled and received either both of their vaccines or the second authorized COVID-19 vaccine. Assessment is ongoing.

MOSAIC-2 (completed):

In this study we will evaluate the safety, tolerability, and immune response (resulting protection) of a third dose of a COVID-19 vaccine currently authorized in Canada (either the Pfizer-BioNTech or Moderna mRNA vaccine) in people who had two doses of COVID-19 vaccines at least six months ago.

Project Details

Funder/sponsor(s): Public Health Agency of Canada (COVID-19 Immunity Task Force)
Lead institution: Clinical Trials Network of the Canadian Immunization Network (CIRN)
Status: Completed
Theme(s): Prevention, Population and Public Health

Project Lead(s): Manish Sadarangani Joanne Langley
Collaborators: Shelly Bolotin, Todd Hatchette, Scott Halperin, Tania Watts, Galit Alter, Joanne Langley
Trainee(s): N/A

First Nations land acknowledegement

Action on Sepsis operates on the traditional, ancestral, and unceded territory of the Coast Salish peoples — xʷməθkʷəy̓əm (Musqueam), Sḵwx̱wú7mesh (Squamish), and Səl̓ílwətaʔ/Selilwitulh (Tsleil-Waututh) Nations. We invite everyone to reflect on the traditional territories and land that they currently work and live on.

Action on Sepsis Research Cluster

Research Excellence Clusters at UBC Vancouver is a joint initiative of the Provost and Vice-President, Academic, UBC Vancouver and the Vice-President, Research and Innovation. Funding support for the clusters is provided by Academic Excellence Funds – UBC Vancouver.

UBC Crest The official logo of the University of British Columbia. Urgent Message An exclamation mark in a speech bubble. Caret An arrowhead indicating direction. Arrow An arrow indicating direction. Arrow in Circle An arrow indicating direction. Arrow in Circle An arrow indicating direction. Bluesky The logo for the Bluesky social media service. Chats Two speech clouds. Facebook The logo for the Facebook social media service. Information The letter 'i' in a circle. Instagram The logo for the Instagram social media service. External Link An arrow entering a square. Linkedin The logo for the LinkedIn social media service. Location Pin A map location pin. Mail An envelope. Menu Three horizontal lines indicating a menu. Minus A minus sign. Telephone An antique telephone. Plus A plus symbol indicating more or the ability to add. Search A magnifying glass. Twitter The logo for the Twitter social media service. Youtube The logo for the YouTube video sharing service.